EGFR and cancer: EGFR is abnormally amplified in a variety of tumors and has been identified as an important target in cancers.36 The imaging process is illustrated in Scheme 1; the mAb–CSPP conjugate emitted very weakly in aqueous solution due to the non-radiative decay of the excited state caused by the free intramolecular rotation, while it became highly emissive after internalization induced by EGFR mediated endocytosis.