SOD1 and myocardial ischemia: The experiments demonstrated the following important findings: (1) autophagy and apoptosis levels markedly increased during myocardial ischemia under excessive oxidative stress both in vitro and in vivo; (2) the regional inflammation response was more serious in SOD1−/− mice after AMI; (3) NaHS pretreatment decreased autophagy and apoptosis in the ischemic myocardium under oxidative stress both in vivo and in vitro; and (4) H2S alleviated the inflammation response in ischemic heart tissues under oxidative stress in vivo.