Carrier individuals of the variant allele of CYP2E1 -1293G>C/-1053C>T (rs3813867/rs2031920) who are also exposed to polycyclic aromatic derivatives may have a high CYP2E1 activity and are prone to develop hematological malignancies, such as AML and ALL. Here, CYP2E1 is linked to hematologic disorder.