IL18 and herpes simplex infectious disease: Besides, pathways including the proinflammatory cytokine genes were also studied, such as hsa05164: Influenza A (TNF, IL-6, IL-18, and IFNA1; p value 0.3256); hsa04620: Toll-like receptor signaling pathway (TNF, IL-6, and IFNA1; p value 0.2185); hsa05168: Herpes simplex infection (TNF, IL-6, IFNA1, and IL-15; p value 0.4868).