IFNG and malaria: In terms of malaria pathogenesis, it may be hypothesized that P. falciparum parasites evade parasite clearance by modulating the host immune system such that IL-10 that has been associated with susceptibility to malaria [27] becomes elevated and IFN-γ that has antiparasitic effect becomes downregulated, thus creating a host environment that may favor propagation of P. falciparum.