The high IL-10 response during clinical malaria episodes demonstrated in infants born to mothers with placental malaria in this study may also indicate a possible inhibition of Th2 cytokine response accompanied with high production of IL-10, leading to disruption of Th1/Th2 balance, curtailing the inhibition of P. falciparum replication, a role played by IFN-γ [34]. The gene discussed is IFNG; the disease is malaria.