LMNA and Hutchinson-Gilford progeria syndrome: HGPS is a segmental premature aging disease that affects mesenchymal lineages and is caused by progerin, a truncated and farnesylated form of Lamin A. HGFP-iMSCs exhibit abnormalities including increased nuclear dysmorphology, DNA damage, and an accumulation of calponin-staining inclusion bodies, which are all properties consistent with fibroblasts isolated from HGPS patients.