In addition to the upregulation of HOXA4, HOXA9, and HOXD10 in CRC [49, 50, 58], the PBX genes are also overexpressed in CRC, which correlates with invasive potential in vitro and lymph node invasion, distant metastasis, advanced TNM stage, and poor overall survival of patients [102]. Here, HOXA4 is linked to colorectal carcinoma.