A significant increase in CRP serum value was associated with an increase in CRC stage (from 7.2 (2.3-13.0) mg/L in stage II to 38.6 (21.4-74.5) mg/L in stage IV, p <0.001), whereas MMP-9 serum level was significantly higher in stage III (458.4 (447.0-464.1) ng/mL) and stage IV (459.7 (453.2-469.6) ng/mL) compared to MMP-9 serum value in stage II CRC (434.8 (373.3-447.4) ng/mL) (p <0.001). This evidence concerns the gene MMP9 and colorectal carcinoma.