IL-6 serum concentration was significantly higher in the stage IV (28.8 (10.4-75.6) pg/mL) compared to stage III (6.5 (0.2-21.3) pg/mL) and stage II CRC (2.5 (0.0-4.0) pg/mL) (p <0.001). The gene discussed is IL6; the disease is colorectal carcinoma.