In recent years the pleiotropic cytokine interleukin-6 (IL-6) and its intracellular signaling pathways, mostly JAK1/2-Stat3, attracted the attention of researchers as a possible link that connecting chronic inflammation and CRC promotion, although the mechanisms of its activation and the contribution to the pathogenesis of chronic inflammatory diseases and cancer are not fully understood [6–8]. This evidence concerns the gene IL6 and colorectal carcinoma.