That research confirmed a significant correlation between MMP-9 and IL-8 serum levels precisely in stage III CRC, while our study confirmed a significant positive correlation between MMP-9 and IL-6 serum levels, as well as between MMP-9 and CRP serum levels in all patients with CRC indicating the mutual stimulated interaction of these biomarkers in colorectal carcinogenesis. The gene discussed is IL6; the disease is colorectal carcinoma.