MMP9 and colorectal carcinoma: However, IL-6, CRP, and MMP-9 serum concentrations were significantly higher in CRC patients with N1 lymph node status (1-3 regional metastatic lymph nodes) and N2 involvement of regional lymph nodes (4 or more metastatic lymph nodes) compared to patients with absence of invasion in regional lymph nodes (N0) (p <0.001).