With regard to the depth invasion of the bowel wall (pT), CRP serum level was increased with increasing the depth of tumor invasion from pT2 to pT4 bowel wall infiltration (from 17.75 (7.3-20.25) mg/L to 29.7 (14.7-50) mg/L, p <0.05), while there were no important difference in IL-6 and MMP-9 serum levels between the patients with pT2-pT4. This evidence concerns the gene IL6 and neoplasm.