The hyperphosphorylation of GluN2B at Tyr1472 correlates well with the role played by GluN2B in triggering NMDAR hyperfunctioning during inflammatory pain [53] and could be involved in the mechanisms of neuroinflammation that contributes to motor neuron degeneration in ALS [54, 55]. This evidence concerns the gene GRIN2B and amyotrophic lateral sclerosis.