WIKIM30 treatment restored the skin epidermis and decreased the number of CD4+ T cells and B cells as well as Th2 cytokine expression in the PLN (Figure 3) of AD model mice, whereas the proportion of Tregs in the MLN (Figure 4) as well as in the PLN (Figure S4) was increased in the WIKIM30-treated group. This evidence concerns the gene CD4 and Alzheimer disease.