IL1B and hereditary spastic paraplegia: They have demonstrated that serum Gd-IgG1, urinary IgA, IgG, IgM, neutrophil gelatinase-associated lipocalin, IL-1β, IL-6, IL-8, IL-10, IgA-IgG, and IgA-sCD89 complexes were associated with nephritis while urine IgA at disease onset could predict poor renal outcome in IgAV/HSP patients (72).