The evidence that many of the Notch target genes encoding for cytokines, i.e., IL-1β, IL-6, IL-8, CCL2, and CCL5 (31, 33, 173, 195), above reported in different tumor settings are negatively regulated by Notch during cancer cell senescence underlines that Notch signaling outcome is highly context dependent. This evidence concerns the gene IL1B and cancer.