Notch pathway has been frequently reported to positively regulate CCL2 expression (31), although this effect seems to be cell type specific, indeed in experimental liver fibrosis and patients with acute-on-chronic liver failure Dll4 is inversely associated to CCL2 (194) and in the melanoma cell line M624 silencing of the Notch coactivator MAML1 results in CCL2 mRNA and protein upregulation (195). The gene discussed is CCL2; the disease is acute-on-chronic liver failure.