CXCR4 and neoplasm: Indeed, CXCR4 genetic deletion in murine hematopoietic progenitors abrogated ICN1 ability to induce leukemogenesis (87), but DAPT treatment failed to inhibit CXCR4 expression either in cell lines or primary cells (88), suggesting that an indirect and more complex mechanism of cooperation between these two pathways may be crucial in promoting tumor progression.