DLL4 and central nervous system cancer: Conversely, as expected, the inhibition of Notch in mouse models of glioma, lymphoma, fibrosarcoma, colorectal, lung, and mammary gland tumors, by systematic retroviral delivery of soluble blocking version of Dll4 or anti-Dll4 antibodies increased VEGFR expression in endothelial cells, vessel branching and density of the tumor vasculature that led to reduced tumor growth due to poor perfusion of tumor vessels and increased hypoxia (226, 227).