CD8A and neoplasm: The possible mechanisms underlying this effect could rely on the positive regulation of the adaptive immune response via stimulation of the production of cytokines and chemokines such as IFN-γ, CXCL9, and CXCL, recruitment of CD4+, CD8+ T cells (159), DCs (157), and neutrophils (161) to tumor sites, stimulation of NK cell activity (157), generation and activation of CTLs (162).