Interleukin 10 released in TME exerts its immunosuppressive function in different ways: (1) unbalancing Th1 vs Th2 tumor-specific immune responses; (2) mediating the differentiation and activation of Tr1 cells involved in immunosuppression (107, 108); (3) inhibiting the production of pro-inflammatory cytokines and mediators such as IL-1, IL-6, IL-12, and tumor necrosis factor α (TNFα) by macrophages and DCs; (4) preventing the differentiation of DCs from monocytes and their maturation (109). This evidence concerns the gene TNF and neoplasm.