KDR and breast cancer: Here, besides the reported Notch-mediated increases of the expression of IL-1β, VEGF, and VEGFR2, the authors demonstrate that IL-1β signaling is required for the positive regulation of Notch receptors induced by leptin (190); moreover, beside the immunosuppressive effect of Notch signaling reported above, Notch, IL-1β and leptin crosstalk outcome mediates other key features including cell proliferation, survival, migration, and angiogenesis in breast cancer (190) and likely in other tumors including pancreatic and endometrial cancer (189, 191).