TNFα immunosuppressive function includes downregulation of TCR signaling and DC function, promotion of T cell apoptosis, activation of Tregs, induction of tumor cell dedifferentiation with a consequent reduced expression of immunogenic antigens and impaired recognition by cytotoxic T cells, impaired differentiation of immature MDSCs with increased suppressive activity resulting in T and NK cell dysfunction and finally inducing other cytokines that can inhibit cell-mediated immunity (130–134). This evidence concerns the gene TNF and neoplasm.