TGFB1 and neoplasm: In addition, Notch activation in tumor cells potentiates TGF-β signaling by promoting the secretion of the urokinase-type plasminogen activator, that allows the maturation of the immature form of TGF-β released by TAMs and further sensitize tumor cells to TGF-β through the upregulation of TGFβR1 (31).