Indeed, Kang et al. (259) recently reported that inhibition of Notch activity, obtained through the use of DN-MAML, results in: (1) senescent phenotype with the release of immune-stimulating cytokines and chemokines that favor the formation of an immunostimulatory microenvironment, including IL-8, IL-1α, IL-1β (260), IFN-γ, IFN-β, CCL2 (195), CCL5, CXCL9, CXCL10, and CXCL11, CCL18; (2) the tumor infiltration by immune cells, such as DCs, NKs, and CD8+ T cells, in in vivo syngeneic animal models. The gene discussed is IL1B; the disease is neoplasm.