TNF and melanoma: Further studies performed on murine models of Lewis lung carcinoma, colon carcinoma, thymoma, and melanoma, showed that the expression of NF-kB-p65, a key mediator of TNFα, is associated to increased levels of Jagged1 and 2 in tumor-infiltrating MDSCs (137), suggesting that TNFα may positively regulate the expression of Jagged ligands.