Feig et al. demonstrated that in pancreatic cancer the blockade of CXCL12 produced by tumor-associated fibroblasts promotes CD3+ T-cells recruitment and restores the sensitivity to the antagonists of the checkpoint inhibitors programmed cell death-1 (PD-1) and cytotoxic T-lymphocyte-associated protein 4 (CTLA-4) (81). This evidence concerns the gene CTLA4 and pancreatic neoplasm.