CXCL8 and neoplasm: The evidence that many of the Notch target genes encoding for cytokines, i.e., IL-1β, IL-6, IL-8, CCL2, and CCL5 (31, 33, 173, 195), above reported in different tumor settings are negatively regulated by Notch during cancer cell senescence underlines that Notch signaling outcome is highly context dependent.