Consistently, lung cancer cells treated with the Notch inhibitors, DBZ and DAPT, showed a reduced response to TGF-β and a decreased cell growth, indicating that at least in part TGF-β pro-tumorigenic functions are Notch dependent, and suggesting that targeting Notch may represent a promising therapeutic strategy to antagonize TGF-β (9). This evidence concerns the gene TGFB1 and lung carcinoma.