CXCR4 signaling is upregulated by hypoxia or in response to steroid hormones and it is associated with an invasive and metastatic phenotype (77) due to its involvement in several aspects of tumor development and progression such as cell migration, proliferation, resistance to apoptosis, angiogenesis, and development of metastasis (77–80). Here, CXCR4 is linked to neoplasm.