Consistently, it was demonstrated that Jagged1 and Dll4 expressed by lung carcinoma and melanoma cells and Jagged1 expressed by neutrophils triggers Notch1 activation in endothelial cells inducing their senescence along with the expression of chemokines and the adhesion molecule VCAM1, that favor neutrophil infiltration, tumor cell intravasation in tumor vessels and metastasis (216). The gene discussed is JAG1; the disease is melanoma.