VEGFA and neoplasm: High levels of VEGF in TME, derived from the tumor, endothelial, stromal cells, and immune cells such as macrophages and Tregs, induce an aberrant activation of Notch signaling in tumor-associated endothelial cells that promotes the formation of new altered vessels by replicating a dysregulated version of physiologic angiogenesis (213, 223, 224).