Dysregulated polyamine metabolism possibly enhances cancer development.Enhance intestinal barrier integrity and function via stimulating synthesis of intercellular junction proteins[occludin, zonula occludens-1 (ZO-1), E-cadherin].Enhance maturation of intestinal and systemic adaptive immune system.Spermine inhibits pro-inflammatory M1 macrophage activation. This evidence concerns the gene CDH1 and cancer.