In addition, absence of LPS-receptor resisted these adverse features regardless of LPS-infusion or high-fat diet treatments as shown in CD14 (LPS-receptor) knockout mice, indicating that the LPS/CD14 system mediates insulin insensitivity, thus inducing the onset of obesity and obesity-related metabolic disorders (Cani et al., 2007). The gene discussed is INS; the disease is obesity due to melanocortin 4 receptor deficiency.