Single agent BRAFi therapy has generally been replaced by combination BRAFi and MEK inhibition (MEKi): phase III studies demonstrated improved clinical outcomes and significantly delayed resistance compared with BRAFi alone and BRAFi-MEKi combination therapy (vemurafenib/cobimetanib and dabrafenib/trametinib) is now the standard of care for BRAF mutated metastatic melanoma (Flaherty et al., 2012; Larkin et al., 2014). The gene discussed is BRAF; the disease is metastatic melanoma.