We chose an experimental design in which we recorded LFPs from a subset of mice (n = 4) in the chronic stage of epilepsy (3 weeks following SE), then we identified the first long (>30 s) paroxysmal episode in a given recording session (Figure 4A), and sacrificed the animal 30 min later approximately at the peak of Arc mRNA expression kinetics. This evidence concerns the gene ARC and epilepsy.