Note that (i) all mentioned proteins are present in sufficient quantities in the HeLa cells which were used here (Supplementary Table 1); (ii) it is expected that the lowER involves sites of contact between ER and mitochondria and oxidative phosphorylation as an energy source in non-cancer cells; and (iii) activated AMPK was shown previously to lead to reduced cap-dependent translation and therefore ties the lowER to the UPR30. The gene discussed is PRKAA1; the disease is cancer.