As showed in supplementary Fig. 2a, western blot results from our patients' cohort revealed that FZD7 was significantly upregulated in HCC tissues than that in normal tissues, which was consistent with the data from database UALCAN (http://ualcan.path.uab.edu/index.html; supplementary Fig. 2b). The gene discussed is FZD7; the disease is hepatocellular carcinoma.