The mRNA expression level of COL10A1 was significantly associated with tumor size (P = 0.003), lymphatic emboli (P = 0.007), lymph node metastasis (P = 0.000), serosal invasion (P = 0.004), AJCC stage (P = 0.000), and recurrence risk (P = 0.001) (Table 2). This evidence concerns the gene COL10A1 and metastatic malignant neoplasm in the lymph nodes.