Higher CD31 expression was detected in a radial configuration in perivascular regions of tumor tissues injected with SK-Hep1 cells; conversely, tumor masses injected with SPZ1 shRNA-transfected SK-Hep1 cells showed a lower level and a more scattered pattern of CD31 expression (Supplementary Figure S4c and S4d). The gene discussed is SPZ1; the disease is neoplasm.