SPZ1 and hepatocellular carcinoma: The expression levels of SPZ1 were previously shown to be higher in the aggressive hepatoma cell lines SK-Hep1 and HA 22T than in HepG2 and Huh 7 hepatoma cells, while the Alexander hepatoma cell line PLC5, Hep 3B, and benign hepatocytes (Chang liver CNL) had lower or undetectable expression of this protein [13].