Our study is the first to demonstrate that the TWIST1 complex positively regulates EMT progression via upregulation of its downstream target gene VEGF, which is an important tumor metastasis regulator and promoter of several physiological and pathological events including angiogenesis, vascular hyperpermeability, cancer metastasis, and cancer stem cell transition [27, 28]. The gene discussed is VEGFA; the disease is neoplasm.