TNF and Hepatic fibrosis: We found that under HFD feeding, mRNA expressions of interleukin-6 (IL-6), tumor necrosis factor-α (TNF-α), fibrotic genes collagen type III alpha 1(COL3A1) and Laminin in JAZF1-Tg mice were lower than in WT mice (Fig. S2A-D), suggesting that JAZF1 overexpression inhibits inflammatory reaction and liver fibrosis in vivo.