PARP12 and neoplasm: In Fig. 7a, b, the number and size of lung tumors significantly increased in the mice injected with PARP12-deficient QGY-7703 cells compared with those of the wild-type QGY-7703 cells, which formed few metastatic lung tumors in all seven injected mice, suggesting that PARP12 deficiency promoted tumor metastasis in vivo.