Recent comprehensive sequencing data of papillary non-invasive bladder tumors revealed a genomic subtype 2, which is characterized by loss of 9q (including TSC1), increased Ki67 labeling index, upregulated mTORC1 signaling, glycolysis, features of the unfolded protein response, altered cholesterol homeostasis and DNA repair [15]. This evidence concerns the gene TSC1 and urinary bladder neoplasm.