TP53 and neoplasm: Moreover, our FGFR3high/Ki67high subgroup also comprises those neoplasms without any molecular (FGFR3 and/or TP53) alterations defining in this combination a subset of pTa tumors with poor prognosis, i.e., FGFR3 overexpression was associated with unfavorable outcome as previously shown, for instance, for invasive bladder tumors treated with adjuvant chemotherapy [28].