While current research on the role of intracrine steroids focuses on intratumoral androgens, it is important to note that aromatase (CYP19A1), which catalyzes estradiol production from testosterone, is also altered in PCa tissues [43] and CYP19A1 expression could be 30-fold higher than normal in PCa metastatic tissues [44]. This evidence concerns the gene CYP19A1 and posterior cortical atrophy.