However, it is important to note that CyaA plays a diverse role in Bordetella infections through several properties, such as adenylate cyclase activity, pore-forming activity, and potent immunogenicity (45, –, 50), and only adenylate cyclase activity was disturbed by 14-3-3 in CyaAs of B. bronchiseptica and B. parapertussis. Here, ADCY1 is linked to Bordetella Infections.