MAPT and Alzheimer disease: In addition, rs1036819 is also a very strong rQTL for both AD case/control status/Aβ42 (p = 6.2 × 10−8) and tau/Aβ42 (p = 6.17 × 10−5), while rs74025622 is involved in G×G interactions with three other loci (Table 3) (see the first paragraph of “Follow up” in Methods).