CAVIN1 and Qualitative or quantitative defects of caveolin-3: Hence, our combined data suggest that a vulnerability of the sarcolemma in caveolinopathy is not only based on the absence/ detrimental reduction of CAV3 [1]—moreover reflected by decrease of PTRF (Additional file 3: Table S1) but also on the aggregation of proteins important for sarcolemmal integrity and presumably strengthened by altered/prolonged processing of DGC components.