CD8A and colorectal cancer: Similarly, Pagès et al. [5] showed that in colorectal cancer without signs of early metastatic invasion, including vascular emboli, lymphatic invasion, and PNI (collectively referred to as “VELIPI”), increased numbers of CD8+ T cells and high levels of messenger RNA for products of type 1 helper effector T cells and high levels of infiltrating memory CD45RO+ cells were observed.