With the deterioration of tubulointerstitial injury from grade 0 to 3 (Table 3), the patients became older, and presented with higher positivity rate of serum anti-PLA2R antibodies, higher level of urinary protein excretion, lower level of serum albumin, lower level of eGFR, higher percentage of hypertension, and lower level of hemoglobin. This evidence concerns the gene PLA2R1 and Hypertension.