AKT1 and posterior cortical atrophy: In this study, for the first time, we clarified the stimulative effect of miR-146b in the process of tumorigenesis in PCa, via targeting PTEN, and these findings also revealed that the fundamental mechanism through which miR-146b suppressed autophagy to inhibit the viability and proliferation of PCa cells involved the activation of AKT/mTOR pathway.