Might our findings point to treatment strategies for gliomas that incorporate PARP inhibition, as is now standard for patients with breast and ovarian cancers that are associated with mutations of BRCA1 and BRCA2? Unfortunately, recent data from early phase clinical trials in children and adults with recurrent gliomas suggest that the combination of TMZ and ABT-888 may not have the same efficacy in patients with gliomas. This evidence concerns the gene BRCA2 and central nervous system cancer.