The expression of three circRNAs and CADM1 over-regulated significantly in four human osteosarcoma cell lines compared to osteoblast cell line (Fig 10A, p<0.05) and significant down-regulation could be seen in the has-miR-142-5p and has-miR-338-3p (Fig 10B, p<0.05). This evidence concerns the gene CADM1 and osteosarcoma.