Although proliferation and clonogenicity in human mesenchymal stem cells decrease with inhibition of the Hh signalling pathway, this does not influence their differentiation potential.39 Recent studies have shown that CP induces apoptosis and inhibits the proliferation of cancer cells and cancer stem cells.31 Our findings after CP treatment suggest that the Shh signalling pathway is important to the apoptosis of mSKPs. The gene discussed is SHH; the disease is cancer.