SHH and cancer: The ability of GANT‐61 to block the Hh‐Gli pathway has been reported in many preclinical and basic studies.17, 30 GANT‐61 primarily represses self‐renewal in cancer cells via inhibition of the Shh signalling pathway.31, 32, 37 Our data suggest that GANT‐61 causes abnormal spheroid shape formation in vitro.