Shh regulates the self‐renewal of stem cells through canonical and noncanonical hedgehog pathways that are related to the Smo receptor.23, 39 The chemical regulation of Hh signalling may have biomedical applications, such as the treatment of Hh signalling pathway‐related cancers or the differentiation of stem cells.31, 40, 41 The secreted Hh protein binds to Patched1, which represses the activity of Smo in the Hh signalling pathway. This evidence concerns the gene SMO and cancer.