RIOX2 and cancer: Although MINA overexpression was associated with worse survival in lung cancer patients who were staged ‘lymph node negative’ (N0) or ‘possible proximal lymph node metastasis’ (N1) (consistent with the cancer ‘driver’ work reviewed above), MINA expression was associated with improved prognosis in patients with distant lymph node invasion (N2) or ‘distant metastasis likely’ (M1) [31].