To further explore the pathogenesis and carcinogenesis of HBV, in our previous study we used gene microarray technology to screen differentially expressed genes in HepG2 and HepG2.2.15 cells as well as HBV-related HCC tissues and paracancerous tissues and found that CtBP2 was highly expressed in the HepG2.2.15 cells and HCC tissues (data not shown). The gene discussed is CTBP2; the disease is hepatocellular carcinoma.