Our previous report demonstrated that the receptor activator of nuclear factor-кB (NFκB) ligand (RANKL)/receptor activator of NFκB (RANK) is a novel signal that regulates inflammation in microglia and macrophages (M/M) through Toll-like receptors (TLRs) 4 [1], which are important receptors for damage-associated molecular patterns in ischemic stroke [2]. This evidence concerns the gene TNFSF11 and ischemic stroke.