Finally, GSK3β, a suppressor of autophagy signaling, was identified as the direct target gene of miR-1907. Conclusion: miR-1907 accelerates hepatocyte proliferation during liver regeneration by activating autophagy; thus pharmacological intervention regulating miR-1907/autophagy axis may be therapeutically beneficial in liver transplantation and liver failure by inducing liver regeneration. Here, GSK3B is linked to liver failure.