Such redistribution of the Sdc1 in the direction of the epithelium to the stroma in the malignant epithelial tumors [58] is related to the loss of the Sdc1 expression on/in the malignant epithelial cells [59–61], and it precisely means the EMT—when cancer cells lose their Sdc1 by transition from the epithelial to the weaker differentiated mesenchymal phenotype [62, 63]. This evidence concerns the gene SDC1 and cancer.