NMU and obesity due to melanocortin 4 receptor deficiency: Neuromedin U (NMU) is a neuropeptide, synthesized in the lateral hypothalamus and expressed in all mammals.5 NMU‐deficient mice are hyperphagic, obese, and have decreased metabolic activity.6 Conversely, systemic administration of NMU peptide suppresses food intake7 and causes weight loss.8 NMU gene variants have also been associated with obesity,9 whereas studies have also shown NMU to be upregulated in calorie restricted animals.10 Together, these data suggest that NMU plays an important role in regulation of feeding and body weight.