Embryonic development, menstrual cycle, hypoxia, inflammation, and tumor will stimulate angiogenic signals, such as vascular endothelial growth factor (VEGF), angiopoietin-2 (ANG-2), and fibroblast growth factors (FGFs) to sprout new endothelial cells and pericytes or vascular smooth muscle cells [173, 174]. Here, ANGPT2 is linked to neoplasm.