Nevertheless, the fact that elevated serum concentrations of PGRN were also previously observed in other chronic inflammation diseases, such as asthma [25], systemic lupus erythematosus [26], arthritis [27], and neurodegenerative disease [28], suggests this adipokine as a marker of ongoing inflammation, rather than a triggering factor of it. Here, GRN is linked to systemic lupus erythematosus.