Most studies have focused on the role of fractalkine in macrophage-mediated adipose tissue inflammation (8, 15, 16), with previous work demonstrating a role for fractalkine in macrophage recruitment and macrophage-adipocyte adhesion in adipose tissue but, to our knowledge there are no reports of fractalkine-driven migration of T cells in obesity (8). The gene discussed is CX3CL1; the disease is obesity due to melanocortin 4 receptor deficiency.