Secreted fractalkine levels were significantly higher in omentum compared to matched serum regardless of patient obesity status and interestingly, there were significantly higher levels of soluble fractalkine in the omentum of EAC patients with elevated serum CRP, i.e., >5 mg/l compared to those with lower serum CRP, i.e., <5 mg/l (mean: 65.8 versus 13.87 ng/ml, p < 0.05) (Figure 1D; Table 2). This evidence concerns the gene CX3CL1 and obesity due to melanocortin 4 receptor deficiency.