Nonetheless, IL-17A and Th17 cells have potent pro-inflammatory properties including the induction of several mediators dysregulated in SSc, including IL-8, IL-6, monocyte chemotactic protein-1 (MCP-1), matrix metalloproteinases (MMP) by dermal fibroblasts, in addition to enhancing their proliferation capacity (12, 26, 27). The gene discussed is CCL2; the disease is systemic sclerosis.