MICA and familial pancreatic carcinoma: IFN-γ was shown to decrease MICA and, in some cases, ULBP2 expression on human melanoma cell lines (89); Type 1 interferons can reduce H60 expression in the methylcholanthrene (MCA)-induced mouse model of fibrosarcoma (90) or increase MICA/B surface expression on human pancreatic cancer cell lines (91).