KLRK1 and Disorder of lipid metabolism: In the apolipoprotein E-deficient mouse model of lipid metabolic disorder, the presence of NKG2D led to high production of inflammatory cytokines (such as IL-6, IL-12, and IFNγ) and the accumulation of NK cells, iNKT cells, and macrophages, resulting in a higher level of liver damage when compared to Klrk1−/− mice and to wild-type mice treated with NKG2D blocking antibodies (137).