Finally, the DEN-induced HCC model recapitulates similar features described in human hepatitis and HCC including: (i) elevated levels of NKG2D and NKG2D ligands, (ii) expression of NKG2D ligands on healthy tissue, (iii) evidence for a high CD8+ T cell infiltrate that correlates with tissue damage and HCC, and (iv) potential dysfunction in NK cell subsets. This evidence concerns the gene KLRK1 and Hepatitis.