Given that asthma in humans is a heterogeneous disease with multiple endotypes/subphenotypes (12–14), it is possible that BN are representative of the extreme end of the Th2high spectrum, with a low neutrophilic/type I IFN responses at baseline and heightened Th2 bias (5, 6), whereas the Balb/c model may represent a more mixed granulocytic Th2 responder phenotype (14). The gene discussed is IFNA1; the disease is asthma.