NLRP3 and ischemic cardiomyopathy: An augmented function of NLRP3 inflammasome has been proposed to play a role in multiple human diseases, such as auto-inflammatory disease (Hoffman and Wanderer, 2010), diabetes (Vandanmagsar et al., 2011), atherosclerosis (Duewell et al., 2010; Baldrighi et al., 2017), and ischemic cardiomyopathy (Kawaguchi et al., 2011; Mezzaroma et al., 2011; Sandanger et al., 2013; Liu et al., 2014; Toldo et al., 2016).