A number of studies have illustrated a central role of NLRP3 inflammasome in murine models of ischemic and non-ischemic cardiomyopathies (Mezzaroma et al., 2011; Bracey et al., 2013; Liu et al., 2014; Toldo et al., 2016; Valle Raleigh et al., 2017). The gene discussed is NLRP3; the disease is ischemic cardiomyopathy.