The observed reduction in prohibitin observed here, following CBD treatment, may thus be an important factor in contributing to the sensitisation of cancer cells to chemotherapeutic agents, as previously shown for CBD in glioblastoma (Torres et al., 2011), in addition to affecting EMV release due to changes in mitochondrial function caused partly by prohibitin and STAT3 downregulation following CBD exposure. Here, PHB1 is linked to glioblastoma.