This approach used within this work, the measurement of mRNA, protein and activity level of MMP-2 and MMP-9 on a long-term treatment, together with the expression of TIMP-1, allows us to validate the complex modulation of these molecules involved in the pathogenesis of liver fibrosis by Sy-HPBCD and Sy-RAMEB, in order to counteract the CCl4-induced damage. Here, MMP2 is linked to Hepatic fibrosis.