Moreover our results totally deviate from the study of Pandey et al. (2011) in which it has been reported that hyperglycemia potentiates the cytotoxicity of carboplatin- and 5-FU-treated breast cells cultured in HG by increasing ROS levels and reducing the expression of P-glycoprotein that promotes cell killing by increasing drug accumulation. Here, ABCB1 is linked to Hyperglycemia.