The addition of DOX at 5 and 10 μM for 24 h and of 5-FU at 50 μM for 72 h down regulated much more the expression of Bcl-2 and Bcl-XL in conditions of euglycemia than in hyperglycemia in both HT29 and LOVO cells. The gene discussed is BCL2; the disease is Hyperglycemia.