BCL2 and Hyperglycemia: Considering the increase of the ratio Bax/Bcl-2 and Bax/Bcl-XL as an indicator of susceptibility to apoptosis, in both HT29 and LOVO cells, the state of hyperglycemia abolished the pro-apoptotic effects of DOX and 5-FU by decreasing the ratio Bax/Bcl-2 and Bax/Bcl-XL (Figures 9, 11 and Supplementary Figures S2, S4).