If the increased expression and activity of MRP1 in LOVO cells cultured in HG could partially explain the decreased intracellular amount of DOX, the effectiveness of DOX on HT29 cells cultured in HG is to be attributed to other molecular mechanisms, among them changes in expression/function of pro- and anti-apoptotic factors, defects in the cell cycle, and/or in expression/function of the molecular targets of anticancer drugs, and enhanced ability of cancer cells to repair anticancer drug-induced DNA damage (Meyerhardt et al., 2012). Here, ABCC1 is linked to cancer.