DNAH8 and Hyperglycemia: Furthermore, in euglycemia DOX 5 and 10 μM 24 h significantly increased the lesion rate in D-loop and encoding ATPase synthesis regions (5- and 10-fold increase, respectively), whereas in hyperglycemia the increase was only about 2.5 and 5 times, respectively (Figures 4B,D - I,II).