In addition to this evidence, as we could not exclude that HG exposure also acted on the onset of MDR through the overexpression of ABC transporters, we investigated whether the effect of hyperglycemia on the decreased cell viability and cytotoxicity induced by DOX and 5-FU may be explained by a change in the expression and activity of Pgp and/or the MDR-related proteins, among which MRP1, 5 and 8, and BCRP. This evidence concerns the gene ABCC1 and Hyperglycemia.