As depicted in Figure 7, compared with the control group, the phosphorylated form of IκB, p38, JNK, and ERK was increased significantly at 30 and 60 min following LPS treatment, whereas UTI treatment markedly depressed LPS-induced IκB, p38, JNK, and ERK phosphorylation. The gene discussed is MAPK8; the disease is bacterial urinary tract infection.