Compared with the control group, the ratio of p-P38/P38, p-IκB/i-κb, p-JNK/JNK, and p-ERK/ERK in PMVECs was increased significantly at 30 min and 60 min following LPS treatment; it was markedly depressed when given UTI treatment (Figure 7). This evidence concerns the gene MAPK8 and bacterial urinary tract infection.