CLDN5 and bacterial urinary tract infection: In PMVECs of UTI+LPS group, immunofluorescence intensity of claudin-5 (Figure 4B) and ZO-1 (Figure 4C) was evidently increased when compared with the respective LPS group; increase in claudin-5 protein level by Western blot was about 50% when compared with the LPS group (Figure 4E); ZO-1 intensity was also substantially increased to approximately 100% when compared with the LPS group (Figure 4F).