Two decades ago, Drs. Mark Smith and George Perry showed iron accumulation associated with the histological hallmarks of Alzheimer’s disease; Aβ plaques and NFTs (Smith et al., 1997) while Kennard et al. (1996) found that serum levels of the iron binding protein MELANOMA-ASSOCIATED ANTIGEN p97 (MFI2) were distinctly higher in individuals with Alzheimer’s disease compared to cognitively normal controls. The gene discussed is MELTF; the disease is early-onset autosomal dominant Alzheimer disease.