The failure of autophagic flux observed in both LOsAD brains (Nixon et al., 2005; Nixon, 2007) and in fibroblasts from individuals with EOfAD due to PSEN1 mutations (Lee J.H. et al., 2010) implies an inability to recycle iron held within defective mitochondria and/or stored in FERRITIN. The gene discussed is PSEN1; the disease is early-onset autosomal dominant Alzheimer disease.