The Alzheimer’s disease-pathogenic ε4 allele of APOE (APOE4) caused significantly lower levels of particular autophagy-critical gene transcripts compared to the non-pathogenic ε3 allele (APOE3) both in Alzheimer’s disease brains and in a transfected astroglioma cell line (Parcon et al., 2017). This evidence concerns the gene APOE and Alzheimer disease.